The female hormones estrogen and progesterone rewire the brains of mice to prepare them for motherhood, according to researchers at the UK’s Francis Crick Institute.
Their findings, just published in Science under the title “Hormone-mediated neural remodeling orchestrates parenting onset during pregnancy,” show that these natural chemicals work on a small number of neurons in the brain to switch on parental behavior even before offspring arrive, resulting in stronger and more-selective responses to the pups.
It is well known that while virgin female rodents don’t show much interaction with pups, mothers spend most of their time looking after young. It was thought that hormones released when giving birth are most crucial for this onset of maternal behavior.
However, earlier research also showed that rats that have given birth by caesarean section and virgin mice exposed to pregnancy hormones still display this maternal behavior, suggesting that hormone changes already during pregnancy may be more important.
In the current study, the researchers found that female mice indeed showed increased parental behavior during late pregnancy and that exposure to pups wasn’t necessary for this change in behavior. They found that a population of nerve cells (called galanin-expressing neurons) in an area of the brain called the medial preoptic area in the hypothalamus that is associated with parenting was impacted by the female hormones.
What happens in humans
The researchers believe the brain may also be rewired in a similar way during pregnancy in humans, as the same hormonal changes are expected to impact the same areas of the brain. This could influence parental behavior alongside environmental and social cues.
Brain recordings showed that estrogen simultaneously reduced the baseline activity of these neurons and made them more excitable, whereas progesterone rewired their inputs, by recruiting more synapses (sites of communication between neurons).
Making these neurons insensitive to hormones completely eliminated the onset of parental behavior during pregnancy. Mice failed to show parental behavior even after giving birth, suggesting there is a critical period during pregnancy when these hormones take effect.
While some of these changes lasted for at least a month after giving birth, others seem to be permanent, suggesting pregnancy can lead to long-term rewiring of the female brain.
Dr. Jonny Kohl, group leader of the state-dependent neural processing laboratory at Crick, said: “We know that the female body changes during pregnancy to prepare for bringing up young. One example is the production of milk, which starts long before giving birth. Our research shows that such preparations are taking place in the brain, too.”
He added that “we think that these changes, often referred to as ‘baby brain,’ cause a change in priority – virgin mice focus on mating, so don’t need to respond to other females’ pups, whereas mothers need to perform robust parental behavior to ensure pup survival. What’s fascinating is that this switch doesn’t happen at birth – the brain is preparing much earlier for this big life change.”
Rachida Ammari, another postdoctoral fellow at Crick and first author along with doctoral Francesco Monaca, said: “We’ve shown that there’s a window of plasticity in the brain to prepare for future behavioral challenges. These neurons receive a large number of inputs from elsewhere in the brain, so now we’re hoping to understand where this new information comes from.”
The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease and to translating their findings into new ways to prevent, diagnose, and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.
