The World Health Organization (WHO) has reported continued circulation of all known clades of the mpox virus (MPXV) as countries work to contain outbreaks across multiple regions. In its latest External Situation Report #60, covering data up to late November 2025, the agency notes that while global case numbers are trending downward, the risk of sustained community transmission remains if outbreaks are not rapidly controlled.
According to WHO, 44 countries reported 2,501 new confirmed mpox cases and 12 deaths in October 2025, representing a global case fatality ratio of 0.5%. The African Region accounted for roughly 75% of all new infections during the month, although most WHO regions — with the exception of South‑East Asia — recorded declines compared with September.
Across Africa, 21 countries reported active transmission between 12 October and 23 November, with 1,734 confirmed cases and 10 deaths (CFR 0.6%). The highest burdens were recorded in the Democratic Republic of the Congo, Liberia, Ghana, Kenya and Uganda, all of which have shown decreasing case trends in recent weeks.
The report also highlights new geographic developments. Mali confirmed its first mpox case, linked to recent travel from Guinea, with genomic sequencing underway to determine the clade. Greece detected clade Ib MPXV for the first time, while imported clade Ib infections were identified among travellers in Belgium, Germany, Greece and the United Kingdom.
Since the previous update, at least 15 clade Ib cases have been detected among individuals who self‑identify as men who have sex with men. Outside Africa, local transmission of clade Ib continues in Italy, the Netherlands, Portugal, Spain, the United States and Malaysia, underscoring the virus’s ongoing global reach.
WHO continues to urge countries to maintain surveillance, strengthen response capacity and ensure rapid containment to prevent further spread.
